Positional Information and Whorl Morphogenesis inPolysphondylium
نویسندگان
چکیده
منابع مشابه
Positional information, positional error, and readout precision in morphogenesis: a mathematical framework.
The concept of positional information is central to our understanding of how cells determine their location in a multicellular structure and thereby their developmental fates. Nevertheless, positional information has neither been defined mathematically nor quantified in a principled way. Here we provide an information-theoretic definition in the context of developmental gene expression patterns...
متن کاملEvolution and Morphogenesis of Differentiated Multicellular Organisms - Autonomously Generated Diffusion Gradients for Positional Information
Development is the powerful process involving a genome in the transformation from one egg cell to a multicellular organism with many cell types. The dividing cells manage to organize and assign themselves special, differentiated roles in a reliable manner, creating a spatio-temporal pattern and division of labor. This despite the fact that little positional information may be available to them ...
متن کاملMorphogenesis by coupled regulatory networks: reliable control of positional information and proportion regulation.
Based on a non-equilibrium mechanism for spatial pattern formation we study how position information can be controlled by locally coupled discrete dynamical networks, similar to gene regulation networks of cells in a developing multicellular organism. As an example we study the developmental problems of domain formation and proportion regulation in the presence of noise, as well as in the prese...
متن کاملPositional information, in bits.
Cells in a developing embryo have no direct way of "measuring" their physical position. Through a variety of processes, however, the expression levels of multiple genes come to be correlated with position, and these expression levels thus form a code for "positional information." We show how to measure this information, in bits, using the gap genes in the Drosophila embryo as an example. Indivi...
متن کاملQualitative Representation of Positional Information
A framework for the qualitative representation of positional information in a two-dimensional space is presented. Qualitative representations use discrete quantity spaces, where a particular distinction is introduced only if it is relevant to the context being modeled. This allows us to build a flexible framework that accommodates various levels of granularity and scales of reasoning. Knowledge...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 1996
ISSN: 0012-1606
DOI: 10.1006/dbio.1996.0324